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![PKA[C] Mouse, Unlabeled, Clone: 5B, BD 50μg; Unlabeled:Antibodies, Monoclonal](https://assets.fishersci.com/TFS-Assets/CCG/product-images/F882554.jpg-650.jpg)
![PKA[C] Mouse, Unlabeled, Clone: 5B, BD 50μg; Unlabeled:Antibodies, Monoclonal](https://assets.fishersci.com/TFS-Assets/CCG/product-images/F882555.jpg-650.jpg)
PKA[C] Mouse, Unlabeled, Clone: 5B, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 610980
This item is not returnable.
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Description
cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. The levels of expression of the different subunits vary according to cell and tissue type.
Immunofluorescence, Western Blotting
Specifications
| PKA[C] | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human PKA[Cα] subunit aa. 18-347 | |
| 50 μg | |
| Cell Biology | |
| Canine, Human, Mouse, Rat | |
| IgG2b |
| Western Blot | |
| 5B | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
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