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  6. Invitrogen™ VSIG4 Monoclonal Antibody (JAV4), Brilliant Violet™ 650, eBioscience™

Invitrogen™ VSIG4 Monoclonal Antibody (JAV4), Brilliant Violet™ 650, eBioscience™

Product Code. 30535163
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30535163 100 Tests Pack of 100
30534116 25 Tests Pack of 25
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Product Code. 30535163 Supplier Invitrogen™ Supplier No. 416575742

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Description

Mouse Monoclonal Antibody

Description This JAV4 monoclonal antibody recognizes human V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig. There are two variants of human VSIG4 that result from alternative splicing. Isoform 1 is longer and more prevalent than isoform 2, and this JAV4 antibody recognizes both. VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins. It contains one complete V-type Ig domain and one truncated C-type Ig domain. The JAV4 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized. This antibody does not cross-react with mouse or rat VSIG4. Applications Tested This JAV4 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Blocking Buffers When using two or more Super Bright, Brilliant Violet™, Brilliant Ultra Violet™, or other polymer dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401</a>) or Brilliant Stain Buffer (Product # 00-4409-75...

T cell activation by APCs is positively and negatively regulated by members of the B7 family. VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.
TRUSTED_SUSTAINABILITY

Specifications

Antigen VSIG4
Applications Flow Cytometry
Classification Monoclonal
Clone JAV4
Concentration 5 μL/Test
Conjugate Brilliant Violet 650
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene VSIG4
Gene Accession No. Q9Y279
Gene Alias A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Gene Symbols VSIG4
Host Species Mouse
Immunogen Fc-Protein and CHO cells.
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11326
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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