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Vinculin Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16854955 Shop All Proteintech Products
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150 μL
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150µL
20µL
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16854955 150 μL 150µL
16864955 20 μL 20µL
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Product Code. 16854955 Supplier Proteintech Supplier No. 265201AP150UL
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Description

Rabbit Polyclonal Antibody

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.

Specifications

Antigen Vinculin
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene VCL
Gene Accession No. P18206, Q64727
Gene Alias CMD1W, Metavinculin, MVCL, VCL, Vinculin
Gene Symbols VCL
Host Species Rabbit
Immunogen Vinculin Fusion Protein Ag24942
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22330, 7414
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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