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Invitrogen™ VEGF Receptor 3 Monoclonal Antibody (102804)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561817
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
Specifications
| VEGF Receptor 3 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P35917 | |
| FLT4 | |
| S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse VEGFR3/Flt-4, Tyr25-Asp770. | |
| 500 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a |
| ELISA | |
| 102804 | |
| Unconjugated | |
| FLT4 | |
| AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 14257 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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