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Invitrogen™ TIGIT Recombinant Rabbit Monoclonal Antibody (228)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA560303

Product Code. 30535187

  • 429.00€ / 100µL

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Description

Description

TIGIT Recombinant Monoclonal Antibody for ELISA

TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TIGIT
Recombinant Monoclonal
1 mg/mL
PBS with no preservative
Q495A1
TIGIT
Recombinant Human TIGIT protein (Met1-Phe138).
100 μL
Primary
Human
Antibody
IgG
ELISA
228
Unconjugated
TIGIT
ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Rabbit
Protein A
RUO
201633
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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