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Invitrogen™ Thioredoxin 2 Monoclonal Antibody (543317)
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Product Code. 30533723
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Quantity:
100 μg
Unit Size:
100µg
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30533723 100 μg 100µg
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Product Code. 30533723 Supplier Invitrogen™ Supplier No. MA561592

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Description

Mouse Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thioredoxin 2
Applications Western Blot
Classification Monoclonal
Clone 543317
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and no preservative
Gene TXN2
Gene Accession No. P97493, P97615, Q99757
Gene Alias 2510006J11Rik; AI788873; COXPD29; G7746; hypothetical protein LOC402938; LMA1; mitochondrial thioredoxin; MTRX; mt-Trx; thioredoxin 2; Thioredoxin II; thioredoxin nuclear gene encoding mitochondrial protein; thioredoxin TRX2; thioredoxin, mitochondrial; Thioredoxin-1; Thioredoxin2; Thioredoxin-2; TR-II; TRX1; Trx2; TRX-2; Txn2; YGR209C; zgc:77127
Gene Symbols TXN2
Host Species Mouse
Immunogen E. coli-derived recombinant human Thioredoxin-2, Thr60-Gly166.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25828, 56551, 79462
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG1
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