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R&D Systems™ T 0901317

Product Code. 18094502
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18094502 10 mg 10mg
18025772 50 mg 50mg
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Product Code. 18094502 Supplier R&D Systems™ Supplier No. 2373/10
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    159.00€
    150.15€ / 10mg
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Estimated Shipment: 20-11-2026
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Description

A Tocris product, part of R&D Systems. Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Potent, high affinity liver X receptor (LXR) agonist (EC50 ∽ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ∽ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 293754-55-9
Molecular Formula C17H12F9NO3S

Specifications

Quantity 10 mg
Product Line Tocris
Formula Weight 481.33
Purity >98%
Molecular Weight (g/mol) 481.333
Chemical Name or Material T 0901317
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