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Invitrogen™ SPINK1 Monoclonal Antibody (839304)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561831
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
Specifications
| SPINK1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P00995 | |
| SPINK1 | |
| E. coli-derived recombinant human SPINK1, Asp24-Cys79. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Neutralization | |
| 839304 | |
| Unconjugated | |
| SPINK1 | |
| calcium transport inhibitor; Caltrin; ISK1; P12; Pancreatic secretory trypsin inhibitor; pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); PCTT; prostatic secretory glycoprotein; PSTI; PSTI-II; serine peptidase inhibitor Kazal type 1; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 1; serine protease inhibitor, Kazal type 3; Spink 3; Spink1; Spink1l; Spink3; TATI; TCP; Tumor-associated trypsin inhibitor | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 6690 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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