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  6. Invitrogen™ SARS-CoV-2 Beta Spike Protein S1/S2 Chimeric Recombinant Human Monoclonal Antibody (D005)

Invitrogen™ SARS-CoV-2 Beta Spike Protein S1/S2 Chimeric Recombinant Human Monoclonal Antibody (D005)
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Product Code. 30535967
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30535967 100 μg 100µg
30534640 20 μg 20µg
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Product Code. 30535967 Supplier Invitrogen™ Supplier No. MA560604

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Description

Human Recombinant Monoclonal Antibody

Specifically recognize the SARS-CoV-2 Beta Spike ECD (non-RBD Epitope). No cross-reactivity with SARS-CoV-2 wild type, Alpha, Delta, Omicron BA.4/BA.5/BA.5.2, Omicron BA.2.75 variant.. Has cross-reactivity in ELISA with: SARS-CoV-2 Beta (B.1.351) Spike S1+S2 trimer Protein; No cross-reactivity in ELISA with: SARS-CoV-2 Omicron (XBB.1.16) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (XBB.1.5) Spike RBD Protein; SARS-CoV-2 Omicron (XBB.1.5) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (XBB.1) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (XBB) Spike RBD Protein; SARS-CoV-2 Omicron (BQ.1.1) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BQ.1.1) Spike RBD Protein; SARS-CoV-2 Omicron (BF.7) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BA.4.6/BF.7) Spike RBD Protein; SARS-CoV-2 Omicron (BA.4.6) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BA.4/BA.5/BA.5.2) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BA.4/BA.5/BA.5.2) Spike RBD Protein; SARS-CoV-2 Omicron (BA.2.75) Spike RBD Protein; SARS-CoV-2 Omicron (BA.2.75) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BA.2.75) Spike RBD Protein; SARS-CoV-2 Omicron (BA.2.75.2) Spike RBD Protein; SARS-CoV-2 Omicron (BA.2.75.2) Spike S1+S2 trimer Protein; SARS-CoV-2 Omicron (BA.2.3.20) Spike RBD Protein; SARS-CoV-2 Omicron (B.1.1.529) S1+S2 trimer Protein; SARS-CoV-2 Omicron (B.1.1.529) Spike RBD Protein; SARS-CoV-2 Alpha (B.1.1.7) Spike S1+S2 trimer Protein; SARS-CoV-2 Alpha (B.1.1.7) Spike RBD Protein; SARS-CoV-2 Beta (B.1....

The SARS-CoV-2 Beta Spike Protein S1/S2 refers to the specific regions of the spike (S) protein found in the Beta variant of the SARS-CoV-2 virus, which causes COVID-19. The spike protein is essential for the virus's ability to infect host cells and is composed of two main subunits: S1, which contains the receptor-binding domain (RBD) responsible for attaching to the host cell receptor angiotensin-converting enzyme 2 (ACE2), and S2, which facilitates the fusion of the viral and host cell membranes. The S1/S2 cleavage site is a critical point where host proteases cleave the spike protein, activating it for membrane fusion and viral entry. The Beta variant, first identified in South Africa, has mutations in the spike protein, including at the S1/S2 cleavage site, which may affect the virus's transmissibility and resistance to neutralizing antibodies, impacting vaccine efficacy and treatment strategies.
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Specifications

Antigen SARS-CoV-2 Beta Spike Protein S1/S2 Chimeric
Applications ELISA
Classification Recombinant Monoclonal
Clone D005
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Host Species Human
Immunogen Recombinant SARS-CoV-2 Beta Spike ECD Protein.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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