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Invitrogen™ RGMA Monoclonal Antibody (292012)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561081
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Specifications
| RGMA | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q8JG54 | |
| RGMA | |
| Mouse myeloma cell line NS0-derived recombinant chicken RGM-A, Pro150-Asn404 (Asn404Asp), predicted. | |
| 100 μg | |
| Primary | |
| Chicken | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 292012 | |
| Unconjugated | |
| RGMA | |
| BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 395214 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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