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PTK2B (phospho Y579), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Product Code. 16274220
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Quantity:
100 μL
Unit Size:
100µL
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16274220 100 μL 100µL
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Product Code. 16274220 Supplier Abnova Supplier No. PAB29229.100uL

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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human PTK2B.

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen PTK2B
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human PTK2B.
Dilution Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Gene PTK2B
Gene Alias CADTK/CAKB/FADK2/FAK2/FRNK/PKB/PTK/PYK2/RAFTK
Gene Symbols PTK2B
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y579 of human PTK2B.
Purification Method Affinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2185
Test Specificity This antibody detects endogenous levels of PTK2B only when phosphorylated at tyrosine 579.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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