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DDR1 (phospho Y513), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Product Code. 16254220
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Quantity:
100 μL
Unit Size:
100µL
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16254220 100 μL 100µL
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Product Code. 16254220 Supplier Abnova Supplier No. PAB29227.100uL

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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq

Specifications

Antigen DDR1
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1.
Dilution Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (without mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Gene DDR1
Gene Accession No. Q08345
Gene Alias CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE
Gene Symbols DDR1
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y513 of human DDR1.
Purification Method Affinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 780
Test Specificity This antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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