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Invitrogen™ PUM1 Monoclonal Antibody (856332)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561846
This item is not returnable.
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Description
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.
Specifications
| PUM1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q14671, Q80U78 | |
| PUM1 | |
| E. coli-derived recombinant human PUM1, Pro230-Ala372. | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
| Western Blot | |
| 856332 | |
| Unconjugated | |
| PUM1 | |
| AA517475; HsPUM; KIAA0099; mKIAA0099; PUM1; PUMH; PUMH1; pumilio 1; pumilio homolog 1; pumilio RNA binding family member 1; pumilio RNA-binding family member 1; pumilio-1; PUML1; Pumm | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 80912, 9698 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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