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  5. Tocris Bioscience™ PS 1145 dihydrochloride

Tocris Bioscience™ PS 1145 dihydrochloride

Product Code. 18760779
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18750779 50 mg 50mg
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Product Code. 18760779 Supplier Tocris Bioscience™ Supplier No. 4569/10

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Description

Selective IKK inhibitor; orally active

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.
TRUSTED_SUSTAINABILITY

Specifications

Purity >98%
Quantity 10 mg
Product Type PS 1145 dihydrochloride
Molecular Weight (g/mol) 395.67
Inhibitors PS 1145 dihydrochloride

For Research Use Only

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