Invitrogen™ pro-GDF1 Polyclonal Antibody

Description

Reconstitute at 0.2 mg/mL in sterile PBS.

Pro-GDF1, or pro-growth differentiation factor 1, is the precursor form of GDF1, a protein that belongs to the transforming growth factor-beta (TGF-beta) superfamily. GDF1 is involved in various developmental processes, particularly in embryogenesis and the development of the central nervous system and cardiovascular system. During its synthesis, pro-GDF1 undergoes proteolytic processing to become the mature, active form. GDF1 plays a crucial role in the formation of the left-right axis during embryonic development, which is essential for the proper positioning and orientation of internal organs. It is also implicated in the regulation of cell differentiation and growth. Mutations or dysregulation in the GDF1 gene can lead to congenital heart defects, heterotaxy (a condition where the internal organs are abnormally arranged), and other developmental anomalies. Understanding the function and regulation of pro-GDF1 and its mature form is important for elucidating the molecular mechanisms underlying normal development and congenital disorders. Research into pro-GDF1 provides insights into the broader roles of TGF-beta family proteins in growth and differentiation, with potential implications for therapeutic strategies aimed at correcting developmental defects and promoting tissue regeneration.