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  5. Tocris Bioscience™ PHT 427

Tocris Bioscience™ PHT 427

Product Code. 18731558
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50 mg
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18731558 10 mg 10mg
18744988 50 mg 50mg
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Product Code. 18731558 Supplier Tocris Bioscience™ Supplier No. 4598/10

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Description

Dual Akt and PDK1 inhibitor; antitumor

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.
TRUSTED_SUSTAINABILITY

Specifications

Purity >98%
Quantity 10 mg
Product Type PHT 427
Molecular Weight (g/mol) 409.61
Inhibitors PHT 427

For Research Use Only

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