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Gibco™ PeproGMP® Human BDNF Recombinant Protein, PeproTech®

Product Code. 30536290
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25 μg; Unlabeled
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Product Code.
30536290 25 μg; Unlabeled
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Product Code. 30536290 Supplier Gibco™ Supplier No. GMP4500225UG

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Description

Recombinant Protein

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
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Specifications

Accession Number P23560
For Use With (Application) Functional Assay
Formulation Protein with no preservative
Gene ID (Entrez) 627
Name BDNF
Quantity 25 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/μg
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Gene Symbol BDNF
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN MGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Expression System E. coli
Form Lyophilized
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