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Eurofins DiscoverX p38α/SAPK2a Protein, Unactive

Product Code. 17300114
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Quantity:
250 μg
50 μg
Unit Size:
250µg
50µg
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17300114 50 μg 50µg
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Product Code. 17300114 Supplier Eurofins DiscoverX Supplier No. 14252

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Description

Unactive, recombinant GST fusion protein containing full-length human p38α/SAPK2a, for use in Kinase Assays.

p38α/SAPK2a Protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

GenBank L35264

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij35, 50% glycerol, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Liquid at -20°C.
Molecular Weight (g/mol) 67.7 kDa
Quantity 50 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal GST
Expression System Recombinant enzyme expressed in E. coli cells
Protein Form Full-length
Purity or Quality Grade ≥76%
Protein p38 alpha/SAPK2a, unactive
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