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  6. P21 Rabbit anti-Human, Polyclonal, Proteintech

P21 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. 16846693 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
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16846693 20 μL 20µL
16836693 150 μL 150µL
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Product Code. 16846693 Supplier Proteintech Supplier No. 103551AP20UL

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Description

Rabbit Polyclonal Antibody

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

Specifications

Antigen P21
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.39 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDKN1A
Gene Accession No. P38936
Gene Alias CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1
Gene Symbols CDKN1A
Host Species Rabbit
Immunogen P21 Fusion Protein Ag0368
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1026
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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