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Invitrogen™ NPTX2 Monoclonal Antibody (569706)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561872
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
Specifications
| NPTX2 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and no preservative | |
| P47972 | |
| NPTX2 | |
| Mouse myeloma cell line, NS0-derived human Neuronal Pentraxin 2, Gly16-Leu431. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 569706 | |
| Unconjugated | |
| NPTX2 | |
| apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 4885 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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