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Invitrogen™ Nicastrin Polyclonal Antibody

Product Code. 30534572
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Quantity:
100 μg
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30534572 100 μg
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Product Code. 30534572 Supplier Invitrogen™ Supplier No. PA5149001

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Description

Sheep Polyclonal Antibody

Reconstitute at 0.2 mg/mL in sterile PBS.

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nicastrin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with trehalose and no preservative
Gene NCSTN
Gene Accession No. Q92542
Gene Alias 9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
Gene Symbols NCSTN
Host Species Sheep
Immunogen Chinese hamster ovary cell line CHO-derived recombinant human Nicastrin Isoform 1, Asn34-Glu669.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23385
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG
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