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Invitrogen™ NEDD4 Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5149155
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
Specifications
| NEDD4 | |
| Polyclonal | |
| Unconjugated | |
| NEDD4 | |
| AA959633; AL023035; AU019897; cell proliferation-inducing gene 53 protein; E3 ubiquitin-protein ligase NEDD4; E430025J12Rik; HECT-type E3 ubiquitin transferase NEDD4; Kiaa0093; mKIAA0093; NEDD4; NEDD-4; NEDD4 E3 ubiquitin protein ligase; Nedd4-1; Nedd4a; Neural precursor cell expressed developmentally down-regulated protein 4; neural precursor cell expressed, developmentally down-regulated 4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down-regulated gene 4; neural precursor cell expressed, developmentally down-regulated gene 4a; neural precursor cell expressed, developmentally down-regulted gene 4; OTTHUMP00000217840; OTTHUMP00000217841; OTTHUMP00000217842; PIG53; receptor-potentiating factor 1; RPF1 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 17999, 25489, 4734 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P46934, P46935, Q62940 | |
| NEDD4 | |
| E. coli-derived recombinant human NEDD4, Asn630-Gly768. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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