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N4BP2L2 Monoclonal Antibody (OTI7F5), TrueMAB™, OriGene

Product Code. 17593643
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100 μL
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30µL
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17593643 100 μL 100µL
17513653 30 μL 30µL
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Product Code. 17593643 Supplier Origene Technologies Supplier No. TA804202

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Description

Mouse Monoclonal Antibody

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.

Specifications

Antigen N4BP2L2
Applications Western Blot
Classification Monoclonal
Clone OTI7F5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene N4BP2L2
Gene Accession No. Q92802
Gene Alias 92M18.3, CG005, CG016, PFAAP5
Gene Symbols N4BP2L2
Host Species Mouse
Immunogen Full length human recombit protein of human N4BP2L2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10443
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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