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MTDH Mouse anti-Human, Clone: OTI2H4, lyophilized, TrueMAB™

Product Code. 17617641
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Quantity:
100 μg
Unit Size:
100µg
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17617641 100 μg 100µg
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Product Code. 17617641 Supplier Origene Technologies Supplier No. CF803709

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

Antigen MTDH
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI2H4
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene MTDH
Gene Accession No. Q86UE4
Gene Alias 3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
Gene Symbols MTDH
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 70-582 of human MTDH produced in SF9 cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92140
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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