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STEMCELL Technologies Mouse Recombinant IL-15

Product Code. 17129521
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. 17129521

Brand: STEMCELL Technologies 78080.1

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Description

Interleukin 15

  • Interleukin 15 (IL-15) is a four alpha-helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor
  • IL-15 is produced by antigen-presenting cells, T cells, and B cells, as well as epithelial and stromal cells
  • The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/IL-15Rb (CD122) and common gamma chain (CD132)
  • IL-15 binds to IL-15Ra and can then be presented in trans to IL-2/IL-15Rb and common gamma chain on other cells
  • Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans
  • The cytoplasmic domains of IL-2/IL-15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways
  • IL-15 supports the survival and proliferation of CD8+ T cells, and promotes homeostasis of memory T cells

Specifications

Name IL-T, Interleukin-15
Quantity 100 μg
Cell Type Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells
Purity or Quality Grade ≥95%
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