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  6. Monoclonal Anti-DXD & Exatecan Antibody, Rabbit IgG (M1D08), ACROBiosystems

Monoclonal Anti-DXD & Exatecan Antibody, Rabbit IgG (M1D08), ACROBiosystems

Product Code. 31451665 Shop All ACROBiosystems Products
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1 mg
100 μg
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31451665 1 mg
31453475 100 μg
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Product Code. 31451665 Supplier ACROBiosystems Supplier No. DXDMY2290100ug
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Estimated Shipment: 21-10-2026
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Description

Rabbit Monoclonal Antibody

DXD & Exatecan Monoclonal antibody specifically detects DXD & Exatecan in Peptide Samples. It is validated for ELISA.

Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, >t;10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DXD & Exatecan
Applications ELISA
Clone M1D08
Conjugate Unconjugated
Host Species Rabbit
Immunogen DXD-BSA
Purification Method Protein A purified / Protein G purified
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Specifically recognizes the DXd and DXd structurally similar molecules.
Reconstitution Please see Certificate of Analysis for specific instructions.
Target Species Not Applicable
Content And Storage For long term storage, the product should be stored in a lyophilized state at -20°C or lower. -20°C to -70°C for 12 months in lyophilized state, -70°C for 3 months under sterile conditions after reconstitution.
Form Powder
Excitation/Emission Unconjugated
Shipping Condition RT
Purity or Quality Grade Purified
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