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  6. MHC Class II (I-A/I-E) Rat, anti-Mouse, APC, Clone: M5/114.15.2, STEMCELL Technologies

MHC Class II (I-A/I-E) Rat, anti-Mouse, APC, Clone: M5/114.15.2, STEMCELL Technologies

Rat Monoclonal Antibody

POA - 422.55€

Specifications

Antigen MHC Class II (I-A/I-E)
Clone M5/114.15.2
Applications Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Conjugate APC
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17127521
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Stemcell Technologies
100-0290 		25 μg This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on +351 21 425 33 50 for assistance
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17137521
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Stemcell Technologies
100-0291 		100 μg
422.55€
100µg
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Description

Description

  • The M5/114.15.2 (M5/114) antibody reacts with an extracellular epitope on the mouse major histocompatibility complex class II receptor (MHC-II)
  • MHC-II is a heterodimeric transmembrane glycoprotein comprising an α subunit associated non-covalently with a β subunit
  • In mice, MHC-II complexes are designated I-A and I-E and comprise Aα/Aβ and Eα/Eβ heterodimers, respectively
  • Together with the CD3/T cell receptor (TCR) complex and CD4 molecules, MHC-II mediates a critical function in presenting peptides generated from hydrolysis of exogenous antigens by antigen-presenting cells to CD4+ T (helper) cells, thereby either suppressing or inducing an immune response to the peptides
  • The M5/114.15.2 antibody recognizes a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek (but not I-Af, I-Ak, or I-As) MHC class II alloantigens expressed on B cells, dendritic cells, macrophages, monocytes, and activated T cells of mice carrying the H-2b, d, p, q, r, and u haplotypes (but not haplotypes H-2f or H-2s)
  • The M5/114 antibody reportedly inhibits I-A-restricted responses by T cells of the H-2b, d, q, and u (but not H-2f, k, or s) haplotypes
  • It does not react with cells from NOD (H-2g7) mice
Specifications

Specifications

MHC Class II (I-A/I-E)
Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
APC
Mouse
M5/114.15.2
Monoclonal
Rat
Primary
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