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Invitrogen™ mGluR1 Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5148917
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
Specifications
| mGluR1 | |
| Polyclonal | |
| Unconjugated | |
| Grm1 | |
| 4930455H15Rik; ENSMUSG00000075319; G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate metabotropic receptor 1; glutamate receptor; glutamate receptor, metabotropic 1; Gm10828; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; MGLU1; MGLUR1; mGluR1a; nmf373; PPP1R85; protein phosphatase 1, regulatory subunit 85; rcw; SCAR13; wobl | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 2911 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q13255 | |
| Grm1 | |
| Chinese hamster ovary cell line CHO-derived recombinant human mGluR1, Ser33-Ser522. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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