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Invitrogen™ MARCO Monoclonal Antibody (579511)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561232
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.
Specifications
| MARCO | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and no preservative; pH 7 | |
| Q60754 | |
| Marco | |
| Mouse myeloma cell line NS0-derived recombinant mouse MARCO, Gln70-Ser518. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG1 |
| Flow Cytometry | |
| 579511 | |
| Unconjugated | |
| Marco | |
| AI323439; Ly112; macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO; SCARA2; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 17167 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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