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Invitrogen™ KREMEN2 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148534
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Specifications
| KREMEN2 | |
| Polyclonal | |
| Unconjugated | |
| KREMEN2 | |
| 2900054E04Rik; Dickkopf receptor 2; kremen protein 2; KREMEN2; kringle containing transmembrane protein 2; kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; Krm2 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 73016 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q8K1S7 | |
| KREMEN2 | |
| Mouse myeloma cell line NS0-derived recombinant mouse Kremen-2, Gly25-Thr371. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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