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Tocris Bioscience™ ITD 1
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Product Code. 18780499
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18780499 50 mg 50mg
18769917 10 mg 10mg
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Product Code. 18780499 Supplier Tocris Bioscience™ Supplier No. 5068/50

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Description

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Purity >98%
Content And Storage -20°C
Quantity 50 mg
Product Type ITD 1
Molecular Weight (g/mol) 415.52
Inhibitors ITD 1

For Research Use Only

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