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Involucrin Antibody (IVRN/827) - IHC-Prediluted, Novus Biologicals™

Product Code. 18169377 Shop All Bio Techne Products
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7 mL
Unit Size:
7mL
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18169377 7 mL 7mL
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Product Code. 18169377 Supplier Novus Biologicals Supplier No. NBP248274

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Description

Mouse Monoclonal Antibody

Involucrin Monoclonal specifically detects Involucrin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Involucrin
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone IVRN/827
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias involucrin
Gene Symbols IVL
Host Species Mouse
Immunogen Purified involucrin from human keratinocytes (Uniprot: P07476)
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Extracellular Matrix
Primary or Secondary Primary
Gene ID (Entrez) 3713
Test Specificity It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this monoclonal antibody reacts with a 120kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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