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STEMCELL Technologies Human Recombinant TPO

Product Code. 17169841
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17169841 25 μg 25µg
17179841 100 μg 100µg
17189841 1000 μg 1000µg
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Product Code. 17169841 Supplier STEMCELL Technologies Supplier No. 78210

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Description

Thrombopoietin

  • Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis in vitro and in vivo
  • TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets in vivo (Bartley et al.; de Sauvage et al.; Foster et al.; Sohma et al.) TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells
  • It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock & Kaushansky)
  • The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets (Ng et al.)

Specifications

Name c-MPL ligand, Megakaryocyte colony-stimulating factor, MGDF, MKCSF, ML, MPLLG, THCYT1, THPO
Quantity 25 μg
Cell Type Hematopoietic Stem and Progenitor Cells; Mesoderm, PSC-Derived; Pluripotent Stem Cells
Purity or Quality Grade ≥90%
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