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Abnova™ Human PAK4 kinase domain (O96013, 300 a.a. - 591 a.a.) Partial Recombinant Protein

Product Code. 16131850
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Quantity:
10 μg
Unit Size:
10µg
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16131850 10 μg 10µg
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Product Code. 16131850 Supplier Abnova™ Supplier No. P5384.10ug

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Description

Used for Func, SDS-PAGE

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Specifications

Accession Number O96013
Concentration 1 mg/ml
For Use With (Application) Functional Study, SDS-PAGE
Formulation Liquid
Gene ID (Entrez) 10298
Molecular Weight (g/mol) 33.3kDa
Name PAK4 (Human) Recombinant Protein
Preparation Method Escherichia coli expression system
Quality Control Testing Loading 7 ug protein in SDS-PAGE
Quantity 10 μg
Immunogen GPHMSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT The first 4 residues GPHM are from Turbo3C Protease cleavage site. The underlined S is phosphorylated S474.
Storage Requirements Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Regulatory Status RUO
Common Name PAK4
Gene Symbol PAK4
Biological Activity Specific activity: 5,595pmoles/min/μg
Species E. coli
Recombinant Recombinant
Protein Tag None
Expression System Escherichia coli expression system
Form Liquid
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