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ACROBiosystems Human Her2 / ErbB2 Protein, Fc Tag

Product Code. 15866927
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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15866927 100 μg 100µg
15876927 1 mg 1mg
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Product Code. 15866927 Supplier ACROBiosystems Supplier No. HE2H5253100UG

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Description

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.0 kDa. The protein migrates as 125-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_004439.2
Molecular Weight (g/mol) 96.0 kDa
Quantity 100 μg
Source Human Her2, Fc Tag (HE2-H5253) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # P04626-1).
Immunogen Thr 23 - Thr 652
Storage Requirements -20°C
Gene Alias ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Common Name Her2
Conjugate Unconjugated
Species Human
Protein Tag Fc Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Bio-Markers and CD Antigens
Purity or Quality Grade >95% as determined by SDS-PAGE
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