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AcroBiosystems GMP Human TGF-Beta 1 / TGFB1 Protein

Product Code. 31451676
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10 mg
25 μg
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31451676 10 mg
31451651 25 μg
31451642 1 mg
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Product Code. 31451676 Supplier AcroBiosystems Supplier No. GMPTG1H2510mg

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Description

Recombinant Protein

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

Specifications

Accession Number Uniprot
Characterization TGF-beta 1 Structure This protein carries no tag. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa±3 kDa when calibrated against under reducing (R) condition (SDS-PAGE).
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in 100 mM HAC, pH 3.0 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 10 mg
Source GMP Human TGF-Beta 1 Protein (GMP-TG1H25) is expressed from human 293 cells (HEK293). It contains AA Ala 279 - Ser 390 (Accession # ). Predicted N-terminus: Ala 279 Request for sequence
Biological Activity GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) inhibits the GMP Human IL-4 Protein (Cat. No. GMP-L04H26) dependent proliferation the TF-1 cells. The specific activity of GMP Human TGF-Beta 1 Protein is >6.00x10^6 IU/mg, which is calibrated against transforming growth factor β1 (NIBSC code:89/514) (QC tested).∣The activity of GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) was higher than other competing products.∣GMP Human FGF basic Protein (Cat. No. GMP-FGCH17) and GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) could maintain the stemness of hiPSCs with high expression of stem cell genes OCT4, SOX2, and SSEA4 with GMP Human Laminin 521 Protein (Cat. No. GMP-LA5H24).∣The Cell based assay shows that GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) is stable at 37°C for 24 hours.∣The Cell based assay shows that GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG TGF-Beta 1.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human TGF-Beta 1 Protein (Cat. No. GMP-TG1H25) was higher than other competing products.
Purity or Quality Grade 0.95
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