missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. AcroBiosystems GMP Human IL-6 Protein

AcroBiosystems GMP Human IL-6 Protein

Product Code. 31452888
Change view
Click to view available options
Quantity:
1 mg
10 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity
31452888 10 mg
31453643 1 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 31452888 Supplier AcroBiosystems Supplier No. GMPL06H2710mg

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

Specifications

Accession Number Uniprot
Characterization IL-6 Structure This protein carries no tag. The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-29 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation.
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 10 mg
Source GMP Human IL-6 Protein (GMP-L06H27) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Met 212 (Accession # ). Predicted N-terminus: Val 30 Request for sequence
Biological Activity GMP Human IL-6 Protein (Cat. No. GMP-L06H27) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-6 Protein is >1.00x10^8 IU/mg, which is calibrated against human IL-6 WHO International Standard (NIBSC code: 21/308) (QC tested).∣The activity of GMP Human IL-6 Protein (Cat. No. GMP-L06H27) was higher than other competing products.∣GMP Human SCF Protein (Cat. No. GMP-SCFH25), Human Flt-3 Ligand Protein (Cat. No. GMP-FLLH28), GMP Human IL-3 Protein (Cat. No. GMP-L03H18) and GMP Human IL-6 Protein (Cat. No. GMP-L06H27) could support the rapid cell expansion and good cell viability of CD34+ hematopoietic stem cells.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable at 37 °C for 24 hours.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable after freezing and thawing 3 times.∣The Cell based assay shows that GMP Human IL-6 Protein (Cat. No. GMP-L06H27) is stable at 4°C for 6 months.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG IL-6.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human IL-6 Protein (Cat. No. GMP-L06H27) was higher than other competing products.
Purity or Quality Grade 0.95
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.