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AcroBiosystems GMP Human IL-4 Protein

Product Code. 31453222
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10 mg
50 μg
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31453222 10 mg
31452108 50 μg
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Product Code. 31453222 Supplier AcroBiosystems Supplier No. GMPL04H2610mg

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Description

Recombinant Protein

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Specifications

Accession Number Uniprot
Characterization IL-4 Structure This protein carries no tag. The protein has a calculated MW of 15.0 kDa. The protein migrates as 19 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 10 mg
Source GMP Human IL-4 Protein (GMP-L04H26) is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # ). Predicted N-terminus: His 25 Request for sequence
Biological Activity GMP Human IL-4 Protein (Cat. No. GMP-L04H26) stimulates proliferation of TF-1 human erythroleukemic cell line. The specific activity of GMP Human IL-4 Protein is >1.20x10^7 IU/mg, which is calibrated against human IL-4 WHO International Standard (NIBSC code: 88/656) (QC tested).∣The activity of GMP Human IL-4 Protein (Cat. No. GMP-L04H26) was higher than other competing products.∣The Cell based assay shows that GMP Human IL-4 Protein (Cat. No. GMP-L04H26) is stable at 37°C for 24 hours.∣The Cell based assay shows that GMP Human IL-4 Protein (Cat. No. GMP-L04H26) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human IL-4 Protein (Cat. No. GMP-L04H26) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG IL-4.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human IL-4 Protein (Cat. No. GMP-L04H26) was higher than other competing products.
Purity or Quality Grade 0.95
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