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AcroBiosystems GMP Human HGF Protein

Product Code. 31453791
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31453791 1 mg
31452283 50 μg
31451997 10 mg
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Product Code. 31453791 Supplier AcroBiosystems Supplier No. GMPHGFH281mg

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Description

Recombinant Protein

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases , and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, HGF promotes the motility of cardiac stem cells in damaged myocardium. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer.

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases , and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, HGF promotes the motility of cardiac stem cells in damaged myocardium. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer.

Specifications

Accession Number Uniprot
Characterization HGF Structure This protein carries no tag. The protein has a calculated MW of 79.7 kDa. The protein migrates as 83 kDa±3 kDa when calibrated against under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 1 mg
Source GMP Human HGF Protein (GMP-HGFH28) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728 (Accession # ). Predicted N-terminus: Gln 32 Request for sequence
Biological Activity GMP Human HGF Protein (Cat. No. GMP-HGFH28) stimulates the secretion of IL-11 by Saos-2 cells. The specific activity of GMP Human HGF Protein is >6.00 x 10^5 IU/mg, which is calibrated against WHO Hepatocyte Growth Factor (NIBSC code: 96/556) (QC tested).∣The activity of GMP Human HGF Protein (Cat. No. GMP-HGFH28) was consistent with competing product.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable at 37°C for 7 hours.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human HGF Protein (Cat. No. GMP-HGFH28) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG HGF.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human HGF Protein (Cat. No. GMP-HGFH28) was consistent with competing product.
Purity or Quality Grade 0.95
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