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GEMIN8 Monoclonal Antibody (OTI4B12), TrueMAB™, OriGene

Product Code. 17515853
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17515853 100 μL 100µL
17535853 30 μL 30µL
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Product Code. 17515853 Supplier Origene Technologies Supplier No. TA805834

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Description

Mouse Monoclonal Antibody

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Specifications

Antigen GEMIN8
Applications Western Blot
Classification Monoclonal
Clone OTI4B12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene GEMIN8
Gene Accession No. Q9NWZ8
Gene Alias FAM51A1
Gene Symbols GEMIN8
Host Species Mouse
Immunogen Full length human recombit protein of human GEMIN8 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54960
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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