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FLT4 Monoclonal Antibody (OTI8C2), TrueMAB™, OriGene

Product Code. 17547323
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100 μL
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17547323 100 μL 100µL
17567323 30 μL 30µL
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Product Code. 17547323 Supplier Origene Technologies Supplier No. TA807002

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Description

Mouse Monoclonal Antibody

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Specifications

Antigen FLT4
Applications Western Blot
Classification Monoclonal
Clone OTI8C2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene FLT4
Gene Accession No. P35916
Gene Alias FLT-4, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3
Gene Symbols FLT4
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1063-1363 of human FLT4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2324
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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