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DOG1/TMEM16A Antibody (DG1/447) - IHC-Prediluted, Novus Biologicals™
Mouse Monoclonal Antibody
Brand: Novus Biologicals NBP2-48152
This item is not returnable.
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Description
DOG1/TMEM16A Monoclonal specifically detects DOG1/TMEM16A in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Specifications
| DOG1/TMEM16A | |
| Monoclonal | |
| Unconjugated | |
| 10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| ANO1 | |
| Recombinant human canine1/TMEM16A protein (Uniprot: Q5XX6) | |
| 7 mL | |
| Primary | |
| Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%. | |
| Store at 4C. | |
| IgG1 κ |
| Immunohistochemistry (Paraffin) | |
| DG1/447 | |
| Immunohistochemistry-Paraffin | |
| ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A | |
| Mouse | |
| Protein A or G purified | |
| RUO | |
| 55107 | |
| Human | |
| Purified |
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