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CTDSP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16827683 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16827683 20 μL 20µL
16817683 150 μL 150µL
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Product Code. 16827683 Supplier Proteintech Supplier No. 109521AP20UL

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Description

Rabbit Polyclonal Antibody

CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.

Specifications

Antigen CTDSP1
Applications Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CTDSP1
Gene Accession No. P58466, Q9GZU7
Gene Alias CTDSP1, NIF3, NLI IF, NLI interacting factor 3, NLIIF, SCP1, Small CTD phosphatase 1
Gene Symbols Ctdsp1
Host Species Rabbit
Immunogen CTDSP1 Fusion Protein Ag1410
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 227292, 363249, 58190
Target Species Rat, Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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