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Invitrogen™ CD72 Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5149004
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
Specifications
| CD72 | |
| Polyclonal | |
| Unconjugated | |
| CD72 | |
| B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 971 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Flow Cytometry, Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P21854 | |
| CD72 | |
| Mouse myeloma cell line NS0-derived recombinant human CD72, Arg117-Asp359. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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