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Invitrogen™ CD357 (AITR/GITR) Monoclonal Antibody (108619)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561533
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Specifications
| CD357 (AITR/GITR) | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| O35714 | |
| Tnfrsf18 | |
| Mouse myeloma cell line NS0-derived recombinant mouse GITR/TNFRSF18, Met1-His153. | |
| 500 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Western Blot | |
| 108619 | |
| Unconjugated | |
| Tnfrsf18 | |
| Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 21936 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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