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  6. CD267 (TACI) Rat, anti-Mouse, APC, Clone: 8F10, STEMCELL Technologies

CD267 (TACI) Rat, anti-Mouse, APC, Clone: 8F10, STEMCELL Technologies

Product Code. 17199131
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17109141 50 μg 50µg
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Product Code. 17199131 Supplier Stemcell Technologies Supplier No. 60116AZ

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Description

Rat Monoclonal Antibody

  • The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ∼30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts
  • Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo
  • CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF
  • Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells
  • CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens

Specifications

Antigen CD267 (TACI)
Applications Flow Cytometry
Classification Monoclonal
Clone 8F10
Conjugate APC
Host Species Rat
Quantity 100 μg
Primary or Secondary Primary
Target Species Mouse
Isotype IgG2a κ
Cell Type B Cells
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