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CD209 Mouse anti-Human, PerCP-Cy5.5, Clone: DCN46, BD
Mouse Monoclonal Antibody
310.00€ - 610.00€
Specifications
| Antigen | CD209 |
|---|---|
| Clone | DCN46 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PerCP-Cyanine5.5 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15811319
|
BD Biosciences
561766 |
25 Tests |
310.00€
Each |
Estimated Shipment: 14-05-2024
Log in to see stock. |
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|
15829268
|
BD Biosciences
558263 |
100 Tests |
610.00€
Each |
Estimated Shipment: 03-05-2024
Log in to see stock. |
|||||
Description
The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.
Specifications
| CD209 | |
| Flow Cytometry | |
| PerCP-Cyanine5.5 | |
| RUO | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| IgG2b κ | |
| Affinity Purified | |
| DC-SIGN |
| DCN46 | |
| Monoclonal | |
| Mouse | |
| Human | |
| Human Monocyte Derived DC Cells | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
For Research Use Only.