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Invitrogen™ beta-Arrestin 2 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148871
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
Specifications
| beta-Arrestin 2 | |
| Polyclonal | |
| Unconjugated | |
| ARRB2 | |
| AI326910; ARB2; ARR2; ARRB2; arrestin 3; arrestin beta 2; arrestin beta-2; arrestin, beta 2; arrestin-3; AW122872; BARR2; BARRES; beta arr2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; beta-arrestin-2; Non-visual arrestin-3 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 409 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P32121 | |
| ARRB2 | |
| E. coli-derived recombinant human beta-Arrestin 2, Met1-Cys409. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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