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Invitrogen™ beta Arrestin 1 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148870
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Specifications
| beta Arrestin 1 | |
| Polyclonal | |
| Unconjugated | |
| ARRB1 | |
| 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 408 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| P49407 | |
| ARRB1 | |
| E. coli-derived recombinant human beta-Arrestin 1, Met1-Arg418. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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