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  6. 15897618

p21 Mouse anti-Human, Unlabeled, Clone: 6B6, BD

Product Code. 15897618
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Product Code. 15897618 Supplier BD Biosciences Supplier No. 554228

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Description

Mouse Monoclonal Antibody

p21 belongs to a class of tumor suppressors including p16 and p27 which control progression through the cell cycle by inhibiting the activity of cyclin-cdk complexes. p21 is also known as senescent cell-derived inhibitor 1 (Sdi1), wild-type p53-activated fragment 1 (Waf1), Cdk-interacting protein 1 (Cip1), p21 and p53-regulated inhibitor of Cdks (Pic1). p21 mRNA is expressed at higher levels in senescent fibroblasts than in actively growing cells. When introduced into proliferating foreskin fibroblasts, p21 inhibits DNA synthesis and cell cycle arrest. p53 can activate p21 gene expression via a p53 binding site identified in the promoter of the p21 gene.

Host Species: Mouse
Clone: 6B6
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human p21
Formula Weight [Chemical]: 21kDa

Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen p21
Applications Western Blot
Classification Monoclonal
Clone 6B6
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human p21
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1
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For Research Use Only.

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